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Tissue Regeneration: Spatial Control of Cell Gene Expression by siRNA Gradients in Biodegradable Hydrogels (Adv. Healthcare Mater. 5/2015)
Author(s) -
Hill Michael C.,
Nguyen Minh K.,
Jeon Oju,
Alsberg Eben
Publication year - 2015
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201570033
Subject(s) - self healing hydrogels , tissue engineering , gene silencing , regeneration (biology) , microbiology and biotechnology , small interfering rna , gene expression , cell , materials science , nanotechnology , gene , biomedical engineering , rna , chemistry , biology , engineering , biochemistry , polymer chemistry
By silencing specific gene expression, short interfering RNA (siRNA) is a potent biomolecule for regulating cell behavior in tissue engineering applications, and spatially patterning its presentation to cells may ultimately facilitate the engineering of complex tissues. The study by E. Alsberg and team on page 714 demonstrates a hydrogel system that presents a linear gradient of siRNA to encapsulated cells, inducing a spatial gradient of green fluorescent protein expression.