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Photodynamic Therapy: A Multifunctional Probe with Aggregation‐Induced Emission Characteristics for Selective Fluorescence Imaging and Photodynamic Killing of Bacteria Over Mammalian Cells (Adv. Healthcare Mater. 5/2015)
Author(s) -
Gao Meng,
Hu Qinglian,
Feng Guangxue,
Tomczak Nikodem,
Liu Rongrong,
Xing Bengang,
Tang Ben Zhong,
Liu Bin
Publication year - 2015
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201570028
Subject(s) - phototoxicity , photodynamic therapy , fluorescence , photochemistry , biophysics , membrane , bacteria , fluorescence lifetime imaging microscopy , photosensitizer , materials science , chemistry , in vitro , optics , biochemistry , organic chemistry , biology , physics , genetics
A multifunctional probe is developed by B. Liu and co‐workers on page 659 for selective fluorescence imaging and photodynamic killing of both Gram‐positive and ‐negative bacteria over mammalian cells. Based on its aggregation‐induced emission and excited‐state intramolecular proton transfer characteristics, the probe is weakly emissive in aqueous solution, but shows intense fluorescence upon binding to negatively charged bacterial membranes. The antibacterial activity arises from both the dark‐toxicity and the phototoxicity under white light irradiation.