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Tissue Engineering: Development of a Cellularly Degradable PEG Hydrogel to Promote Articular Cartilage Extracellular Matrix Deposition (Adv. Healthcare Mater. 5/2015)
Author(s) -
Sridhar Balaji V.,
Brock John L.,
Silver Jason S.,
Leight Jennifer L.,
Randolph Mark A.,
Anseth Kristi S.
Publication year - 2015
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201570027
Subject(s) - extracellular matrix , cartilage , tissue engineering , materials science , matrix (chemical analysis) , peg ratio , nanotechnology , extracellular , microbiology and biotechnology , biophysics , biomedical engineering , anatomy , medicine , composite material , biology , finance , economics
A cellularly degradable hydrogel based on peptide and protein functionalized PEG is designed on page 702 by M. A. Randolph, K. S. Anseth, and co‐workers to allow local, cell‐mediated remodeling in a manner that promotes cartilage extracellular matrix deposition and leads to increased mechanical properties. The cover depicts encapsulated chondrocytes secreting cartilage‐specific matrix macromolecules (orange fibers and green branches) that remodel and replace the surrounding synthetic network (white lines).