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Antioxidants: Inhibition of Angiogenesis by Antioxidant Micelles (Adv. Healthcare Mater. 4/2015)
Author(s) -
Moriyama Masaki,
Metzger Stéphanie,
van der Vlies André J.,
Uyama Hiroshi,
Ehrbar Martin,
Hasegawa Urara
Publication year - 2015
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201570022
Subject(s) - chorioallantoic membrane , angiogenesis , reactive oxygen species , antioxidant , in ovo , intracellular , chemistry , in vitro , catechol , microbiology and biotechnology , micelle , cancer research , biochemistry , biology , embryo , aqueous solution
The overproduction of reactive oxygen species (ROS) has been associated with the initiation and progression of various diseases including cancer. On page 569, U. Hasegawa and co‐workers show that antioxidant micelles bearing redox‐active catechol moieties efficiently reduce intracellular ROS levels and inhibit ROS‐mediated angiogenesis in the in vitro endothelial cell tube formation assay and the ex ovo chicken chorioallantoic membrane assay.