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Tissue Engineering: Anisotropic Cellular Network Formation in Engineered Muscle Tissue through the Self‐Organization of Neurons and Endothelial Cells (Adv. Healthcare Mater. 3/2015)
Author(s) -
Takahashi Hironobu,
Shimizu Tatsuya,
Nakayama Masamichi,
Yamato Masayuki,
Okano Teruo
Publication year - 2015
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201570020
Subject(s) - tissue engineering , regenerative medicine , smooth muscle , nanotechnology , materials science , myocyte , microbiology and biotechnology , anisotropy , neuroscience , biomedical engineering , stem cell , medicine , biology , physics , quantum mechanics
A technique for organizing tissue anisotropy in engineered tissue is necessary for advanced‐biomedical technologies. On page 356 T. Shimizu and colleagues find that an anisotropic environment composed of multiple myoblast sheets triggers the self‐organization of neurons and endothelial cells, resulting in the formation of oriented cellular networks in the tissue construct. This unique approach is useful for mimicking micro‐structures in native muscle tissue, required for future advances in regenerative medicine.