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Efficient Purification and Release of Circulating Tumor Cells by Synergistic Effect of Biomarker and SiO 2 @Gel‐Microbead‐Based Size Difference Amplification
Author(s) -
Huang Qinqin,
Cai Bo,
Chen Bolei,
Rao Lang,
He Zhaobo,
He Rongxiang,
Guo Feng,
Zhao Libo,
Kondamareddy Kiran Kumar,
Liu Wei,
Guo Shishang,
Zhao XingZhong
Publication year - 2016
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201500981
Subject(s) - microbead (research) , circulating tumor cell , conjugated system , microfluidics , tumor cells , isolation (microbiology) , nanotechnology , computer science , materials science , computational biology , chemistry , microbiology and biotechnology , cancer research , bioinformatics , polymer , cancer , biology , biochemistry , genetics , composite material , metastasis
Microfluidics‐based circulating tumor cell (CTC) isolation is achieved by using gelatin‐coated silica microbeads conjugated to CTC‐specific antibodies. Bead‐binding selectively enlarges target cell size, providing efficient high‐purity capture. CTCs captured can be further released non‐invasively. This stratagem enables high‐performance CTC isolation for subsequent studies.