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Polyanionic Macromolecular Prodrugs of Ribavirin: Antiviral Agents with a Broad Spectrum of Activity
Author(s) -
Hinton Tracey M.,
Zuwala Kaja,
Deffrasnes Celine,
Todd Shawn,
Shi Shuning,
Marsh Glenn A.,
Dearnley Megan,
Wohl Benjamin M.,
Tolstrup Martin,
Zelikin Alexander N.
Publication year - 2016
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201500841
Subject(s) - ribavirin , broad spectrum , prodrug , macromolecule , virology , materials science , nanotechnology , combinatorial chemistry , chemistry , virus , pharmacology , medicine , biochemistry , hepatitis c virus
Macromolecular prodrugs are developed as multiarmed agents against diverse viral pathogens. Lead candidates inhibit infectivity and replication of HIV, Ebola, influenza, measles, RSV, etc—thus being broad‐spectrum antiviral agents.