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Particles for Local Delivery of Proteins Using Intra‐Articular Route
Author(s) -
Khodabandehlou Khosrow,
Tian Shaomin,
Luft James C.,
Khan Saad A.,
DeSimone Joseph M.
Publication year - 2016
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201500797
Subject(s) - computer science , bovine serum albumin , intra articular , service (business) , chemistry , computational biology , medicine , biology , biochemistry , business , pathology , alternative medicine , marketing , osteoarthritis
Designing a vehicle for local delivery of proteins using intra‐articular route is an attractive option to minimize the adverse effects associated with systemic exposure and to maximize the efficacy. Slowly dissolving silylated microparticles are designed with specific size and shape that are capable of extending the retention time of a model protein (bovine serum albumin) in the murine knee joint. No cytotoxicity is observed for the reconstituted formulation when tested against synovial fibroblasts and RAW 264.7 macrophages.