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Development of 3D Microvascular Networks Within Gelatin Hydrogels Using Thermoresponsive Sacrificial Microfibers
Author(s) -
Lee Jung Bok,
Wang Xintong,
Faley Shan,
Baer Bradly,
Balikov Daniel A.,
Sung HakJoon,
Bellan Leon M.
Publication year - 2016
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201500792
Subject(s) - gelatin , self healing hydrogels , microfiber , materials science , capillary action , biocompatible material , nanotechnology , biomedical engineering , chemical engineering , composite material , polymer chemistry , chemistry , medicine , biochemistry , engineering
A 3D microvascularized gelatin hydrogel is produced using thermoresponsive sacrificial poly( N ‐isopropylacrylamide) microfibers. The capillary‐like microvascular network allows constant perfusion of media throughout the thick hydrogel, and significantly improves the viability of human neonatal dermal fibroblasts encapsulated within the gel at a high density.