Development of 3D Microvascular Networks Within Gelatin Hydrogels Using Thermoresponsive Sacrificial Microfibers | Zendy

Lee Jung Bok | Zendy; Wang Xintong | Zendy; Faley Shan | Zendy; Baer Bradly | Zendy; Balikov Daniel A. | Zendy; Sung HakJoon | Zendy; Bellan Leon M. | Zendy

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Development of 3D Microvascular Networks Within Gelatin Hydrogels Using Thermoresponsive Sacrificial Microfibers

Author(s) -

Lee Jung Bok,

Wang Xintong,

Faley Shan,

Baer Bradly,

Balikov Daniel A.,

Sung HakJoon,

Bellan Leon M.

Publication year - 2016

Publication title -

advanced healthcare materials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.288

H-Index - 90

eISSN - 2192-2659

pISSN - 2192-2640

DOI - 10.1002/adhm.201500792

Subject(s) - gelatin , self healing hydrogels , microfiber , materials science , capillary action , biocompatible material , nanotechnology , biomedical engineering , chemical engineering , composite material , polymer chemistry , chemistry , medicine , biochemistry , engineering

A 3D microvascularized gelatin hydrogel is produced using thermoresponsive sacrificial poly( N ‐isopropylacrylamide) microfibers. The capillary‐like microvascular network allows constant perfusion of media throughout the thick hydrogel, and significantly improves the viability of human neonatal dermal fibroblasts encapsulated within the gel at a high density.

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