Premium
Click‐Crosslinked Injectable Gelatin Hydrogels
Author(s) -
Koshy Sandeep T.,
Desai Rajiv M.,
Joly Pascal,
Li Jianyu,
Bagrodia Rishi K.,
Lewin Sarah A.,
Joshi Neel S.,
Mooney David J.
Publication year - 2016
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201500757
Subject(s) - bioorthogonal chemistry , self healing hydrogels , gelatin , tetrazine , click chemistry , norbornene , in vivo , chemistry , cell encapsulation , polymer , polymer chemistry , biophysics , polymer science , organic chemistry , polymerization , microbiology and biotechnology , biology
Injectable gelatin hydrogels formed with bioorthogonal click chemistry (ClickGel) are cell‐responsive ECM mimics for in vitro and in vivo biomaterials applications. Gelatin polymers with pendant norbornene (GelN) or tetrazine (GelT) groups can quickly and spontaneously crosslink upon mixing, allowing for high viability of encapsulated cells, establishment of 3D elongated cell morphologies, and biodegradation when injected in vivo.