Premium
Tuning Reaction and Diffusion Mediated Degradation of Enzyme‐Sensitive Hydrogels
Author(s) -
Skaalure Stacey C.,
Akalp Umut,
Vernerey Franck J.,
Bryant Stephanie J.
Publication year - 2016
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201500728
Subject(s) - self healing hydrogels , dimensionless quantity , degradation (telecommunications) , computer science , diffusion , encapsulation (networking) , kinetics , materials science , cell encapsulation , nanotechnology , chemistry , biological system , physics , thermodynamics , polymer chemistry , computer network , telecommunications , quantum mechanics , biology
Enzyme‐sensitive hydrogels are promising for cell encapsulation and tissue engineering, but result in complex spatiotemporal degradation behavior that is characteristic of reaction‐diffusion mechanisms. An experimental and theoretical approach is presented to identify dimensionless quantities that serve as a design tool for engineering enzyme‐sensitive hydrogels with controlled degradation patterns by tuning the initial hydrogel properties and enzyme kinetics.