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Controlling Shear Stress in 3D Bioprinting is a Key Factor to Balance Printing Resolution and Stem Cell Integrity
Author(s) -
Blaeser Andreas,
Duarte Campos Daniela Filipa,
Puster Uta,
Richtering Walter,
Stevens Molly M.,
Fischer Horst
Publication year - 2016
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201500677
Subject(s) - shear stress , structural integrity , computer science , key (lock) , nozzle , shear (geology) , stress (linguistics) , 3d bioprinting , nanotechnology , mechanical engineering , materials science , engineering , structural engineering , biomedical engineering , tissue engineering , composite material , linguistics , philosophy , computer security
A microvalve‐based bioprinting system for the manufacturing of high‐resolution, multimaterial 3D‐structures is reported. Applying a straightforward fluid‐dynamics model, the shear stress at the nozzle site can precisely be controlled. Using this system, a broad study on how cell viability and proliferation potential are affected by different levels of shear stress is conducted. Complex, multimaterial 3D structures are printed with high resolution. This work pioneers the investigation of shear stress‐induced cell damage in 3D bioprinting and might help to comprehend and improve the outcome of cell‐printing studies in the future.