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Nuclear‐Targeting MSNs‐Based Drug Delivery System: Global Gene Expression Analysis on the MDR‐Overcoming Mechanisms
Author(s) -
Li Xiaoyu,
Pan Limin,
Shi Jianlin
Publication year - 2015
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201500548
Subject(s) - multiple drug resistance , apoptosis , suppressor , drug delivery , mesoporous silica , drug resistance , dna damage , cancer research , drug , gene , dna , nanotechnology , chemistry , biology , pharmacology , materials science , biochemistry , genetics , mesoporous material , catalysis
The biological mechanisms of nuclear‐targeting mesoporous silica nanoparticles (MSNs)‐based DDSs (DOX@NT‐MSNs) in overcoming multidrug resistance of cancer cells are studied. It is interesting to find for the first time that DOX@NT‐MSNs down‐regulate the expression of apoptosis suppressor genes and inhibit DNA repair process by disturbing the p53 pathway.