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Angiogenic Type I Collagen Extracellular Matrix Integrated with Recombinant Bacteriophages Displaying Vascular Endothelial Growth Factors
Author(s) -
Yoon Junghyo,
Korkmaz Zirpel Nuriye,
Park HyunJi,
Han Sewoon,
Hwang Kyung Hoon,
Shin Jisoo,
Cho SeungWoo,
Nam ChangHoon,
Chung Seok
Publication year - 2016
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201500534
Subject(s) - extracellular matrix , angiogenesis , vascular endothelial growth factor , matrix (chemical analysis) , recombinant dna , type i collagen , in vivo , microbiology and biotechnology , materials science , biophysics , chemistry , biology , vegf receptors , biochemistry , cancer research , composite material , genetics , endocrinology , gene
Here, a growth‐factor‐integrated natural extracellular matrix of type I collagen is presented that induces angiogenesis. The developed matrix adapts type I collagen nanofibers integrated with synthetic colloidal particles of recombinant bacteriophages that display vascular endothelial growth factor (VEGF). The integration is achieved during or after gelation of the type I collagen and the matrix enables spatial delivery of VEGF into a desired region. Endothelial cells that contact the VEGF are found to invade into the matrix to form tube‐like structures both in vitro and in vivo, proving the angiogenic potential of the matrix.