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Carbohydrate‐Conjugated Hollow Oblate Mesoporous Silica Nanoparticles as Nanoantibiotics to Target Mycobacteria
Author(s) -
Hao Nanjing,
Chen Xuan,
Jeon Seaho,
Yan Mingdi
Publication year - 2015
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201500491
Subject(s) - oblate spheroid , conjugated system , mesoporous silica , materials science , mesoporous material , nanoparticle , carbohydrate , nanotechnology , chemical engineering , biophysics , chemistry , polymer , composite material , biochemistry , biology , catalysis , physics , atomic physics , engineering
Engineering nanomaterials with enhanced antibacterial activities remains a critical and practical challenge. Hollow oblate mesoporous silica nanoparticles (HOMSNs) are synthesized by a simple protocol of ammonia hydrothermal treatment of oblate mesoporous silica nanoparticles prepared using dibenzyl ether as a cosolvent. When conjugated with trehalose as the targeting ligand, the antibiotic‐encapsulated HOMSNs exhibit high binding affinity and antibacterial efficacy toward mycobacteria.