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Multifunctional Theranostic Nanoplatform for Cancer Combined Therapy Based on Gold Nanorods
Author(s) -
Chen WeiHai,
Yang CaiXia,
Qiu WenXiu,
Luo GuoFeng,
Jia HuiZhen,
Lei Qi,
Wang XiaoYong,
Liu Gang,
Zhuo RenXi,
Zhang XianZheng
Publication year - 2015
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201500453
Subject(s) - photothermal therapy , nanorod , materials science , nanotechnology , in vivo , photoacoustic imaging in biomedicine , drug delivery , cancer therapy , cancer imaging , cancer , radiation therapy , biomedical engineering , cancer research , medicine , surgery , physics , microbiology and biotechnology , optics , biology
Nanomaterials that integrate diagnostic and therapeutic functions within a single nanoplatform promise great advances in revolutionizing cancer therapy. A smart multifunctional theranostic drug‐delivery system (DDS) based on gold nanorods (abbreviated as GNR/TSDOX) is designed for cancer‐targeted imaging and imaging‐guided therapy. In this intelligent theranostic DDS, the active targeting ligand biotin is introduced to track cancer sites in vivo. With the aid of photothermal/photoacoustic imaging, GNR/TSDOX can ablate cancer specifically and effectively. When stimulated with a single near‐infrared (NIR) light source, this NIR light energy is effectively absorbed and converted into heat by GNR/TSDOX for localized photothermal therapy and the increase in temperature also further triggers the cascaded release of the anticancer drug for combined thermo‐chemotherapy. More importantly, the in vivo cure effect can be well guided by regulating the irradiation time and intensity of the NIR light.