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Polymer Supported Directed Differentiation Reveals a Unique Gene Signature Predicting Stable Hepatocyte Performance
Author(s) -
Villarin Baltasar Lucendo,
Cameron Kate,
Szkolnicka Dagmara,
Rashidi Hassan,
Bates Nicola,
Kimber Susan J.,
Flint Oliver,
Forbes Stuart J.,
Iredale John P.,
Bradley Mark,
Hay David C.
Publication year - 2015
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201500391
Subject(s) - induced pluripotent stem cell , somatic cell , stem cell , microbiology and biotechnology , obstacle , cellular differentiation , signature (topology) , cell , hepatocyte , gene , biology , computational biology , genetics , in vitro , political science , embryonic stem cell , geometry , mathematics , law
In theory, pluripotent stem cells can give rise to all somatic cell types found in the human body. The ability to generate renewable sources of human cells has enormous potential to improve human health and wealth. One major obstacle to the routine deployment of stem cell–derived cells is their instability in culture. To tackle this issue a synthetic polymer surface is used.