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Multimodal Nanoparticle for Primary Tumor Delineation and Lymphatic Metastasis Mapping in a Head‐and‐Neck Cancer Rabbit Model
Author(s) -
Muhanidal,
MacDonald Thomas D.,
Chan Harley,
Jin Cheng S.,
Burgess Laura,
Cui Liyang,
Chen Juan,
Irish Jonathan C.,
Zheng Gang
Publication year - 2015
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201500363
Subject(s) - lymph , lymphatic system , primary tumor , metastasis , head and neck cancer , head and neck , positron emission tomography , cancer , medicine , collateral damage , pathology , radiology , computer science , surgery , psychology , criminology
64 Cu‐porphysome nanoparticles enable superior delineation of neoplastic tissues, metastatic lymph nodes, and vascular drainage on head and neck cancer orthotopic rabbit model using positron emission tomography imaging. Additionally, the nanoparticles exhibit selective fluorescence activation in tumor and metastatic lymph nodes, which permits intraoperative real‐time visualization of disease tissues to precisely define surgical margins and prevents collateral damage during surgeries.