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Covalent Incorporation of Trehalose within Hydrogels for Enhanced Long‐Term Functional Stability and Controlled Release of Biomacromolecules
Author(s) -
O'Shea Timothy M.,
Webber Matthew J.,
Aimetti Alex A.,
Langer Robert
Publication year - 2015
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201500334
Subject(s) - library science , management , computer science , economics
Hydrogels with covalently incorporated trehalose are synthesized using thiol‐ene Michael addition. Trehalose hydrogels afford prolonged stabilization and controlled release of model enzymes in vitro and in vivo as well as preservation of protein stability under heat and lyophilization stressors. Strong and ordered hydrogen bonding interactions within covalently incorporated trehalose hydrogels represent a possible mechanism for protein stabilization.