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Selective Vaporization of Superheated Nanodroplets for Rapid, Sensitive, Acoustic Biosensing
Author(s) -
Chattaraj Rajarshi,
Mohan Praveena,
Besmer Jeremy D.,
Goodwin Andrew P.
Publication year - 2015
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201500315
Subject(s) - streptavidin , biosensor , vaporization , computer science , nanotechnology , biotinylation , scalability , biotin , microbubbles , materials science , chemistry , ultrasound , acoustics , physics , database , biochemistry , organic chemistry
Superheated perfluorocarbon nanodroplets exhibit promise as sensitive acoustic biosensors. Aggregation of biotin‐decorated lipid‐shelled droplets by streptavidin greatly increases the yield of bubbles formed by ultrasound‐induced vaporization. Streptavidin is sensed down to 1 × 10 −13 m , with differentiable signal appearing in as little as two minutes, using a scalable assay without washing, processing, or development steps.