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Selenite‐Releasing Bone Mineral Nanoparticles Retard Bone Tumor Growth and Improve Healthy Tissue Functions In Vivo
Author(s) -
Wang Yanhua,
Hao Hang,
Liu Haoming,
Wang Yifan,
Li Yan,
Yang Gaojie,
Ma Jun,
Mao Chuanbin,
Zhang Shengmin
Publication year - 2015
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201500307
Subject(s) - selenium , in vivo , nanoparticle , osteosarcoma , chemistry , biophysics , materials science , cancer research , nanotechnology , medicine , biology , metallurgy , microbiology and biotechnology
Selenite‐doped bone mineral nanoparticles can retard the growth of osteosarcoma in a nude mice model, through sustained release of selenite ions. The selenite ions released from the nanoparticles through a degradation‐mediated fashion inhibit tumor metastasis. Blood routine analysis indicates that selenite ions can also improve the functions of liver, kidney, and heart.