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Dissolvable Base Scaffolds Allow Tissue Penetration of High‐Aspect‐Ratio Flexible Microneedles
Author(s) -
Yagi Satoshi,
Yamagiwa Shota,
Kubota Yoshihiro,
Sawahata Hirohito,
Numano Rika,
Imashioya Tatsuya,
Oi Hideo,
Ishida Makoto,
Kawano Takeshi
Publication year - 2015
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201500305
Subject(s) - materials science , penetration (warfare) , tissue engineering , biomedical engineering , base (topology) , nanotechnology , medicine , mathematics , operations research , engineering , mathematical analysis
Microscale needle technology is important in electrophysiological studies, drug/chemical delivery systems, optogenetic applications, and so on. In this study, dissolvable needle‐base scaffold realizes penetration of high‐aspect‐ratio flexible microneedles (e.g., <5 μm diameter and >500 μm length) into biological tissues. This methodology, which is applicable to numerous high‐aspect‐ratio flexible microneedles, should reduce the invasiveness and provide safer tissue penetrations than conventional approaches.