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Multilayered, Hyaluronic Acid‐Based Hydrogel Formulations Suitable for Automated 3D High Throughput Drug Screening of Cancer‐Stromal Cell Cocultures
Author(s) -
Engel Brian J.,
Constantinou Pamela E.,
Sablatura Lindsey K.,
Doty Nathaniel J.,
Carson Daniel D.,
FarachCarson Mary C.,
Harrington Daniel A.,
Zarembinski Thomas I.
Publication year - 2015
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201500258
Subject(s) - hyaluronic acid , stromal cell , self healing hydrogels , throughput , drug delivery , computer science , drug , chemistry , nanotechnology , cancer research , materials science , medicine , pharmacology , operating system , organic chemistry , wireless , anatomy
Validation of a high‐throughput compatible 3D hyaluronic acid hydrogel coculture of cancer cells with stromal cells. The multilayered hyaluronic acid hydrogels improve drug screening predictability as evaluated with a panel of clinically relevant chemotherapeutics in both prostate and endometrial cancer cell lines compared to 2D culture.