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Inhibition of Cancer Cell Migration by Multiwalled Carbon Nanotubes
Author(s) -
GarcíaHevia Lorena,
Valiente Rafael,
FernándezLuna José L.,
Flahaut Emmanuel,
RodríguezFernández Lidia,
Villegas Juan C.,
González Jesús,
Fanarraga Mónica L.
Publication year - 2015
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201500252
Subject(s) - cytoskeleton , cancer cell , microbiology and biotechnology , microtubule , cell , programmed cell death , materials science , cell growth , actin , biophysics , nanotechnology , chemistry , apoptosis , cancer , biology , biochemistry , genetics
Inhibiting cancer cell migration and infiltration to other tissues makes the difference between life and death. Multiwalled carbon nanotubes (MWCNTs) display intrinsic biomimetic properties with microtubules, severely interfering with the function of these protein filaments during cell proliferation, triggering cell death. Here it is shown MWCNTs disrupt the centrosomal microtubule cytoskeletal organization triggering potent antimigratory effects in different cancer cells.