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Cell Invasion in Collagen Scaffold Architectures Characterized by Percolation Theory
Author(s) -
Ashworth Jennifer C.,
Mehr Marco,
Buxton Paul G.,
Best Serena M.,
Cameron Ruth E.
Publication year - 2015
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201500197
Subject(s) - scaffold , materials science , percolation (cognitive psychology) , percolation theory , nanotechnology , biomedical engineering , engineering , neuroscience , chemistry , psychology , conductivity
The relationship between biological scaffold interconnectivity and cell migration is an important but poorly understood factor in tissue regeneration. Here a scale‐independent technique for characterization of collagen scaffold interconnectivity is presented, using a combination of X‐ray microcomputed tomography and percolation theory. Confocal microscopy of connective tissue cells reveals this technique as highly relevant for determining the extent of cell invasion.