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Targeted Therapy for Breast Cancer Stem Cells by Liposomal Delivery of siRNA against Fibronectin EDB
Author(s) -
Sun Yujin,
Kim Hoe Suk,
Saw Phei Er,
Jon Sangyong,
Moon Woo Kyung
Publication year - 2015
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201500190
Subject(s) - cancer research , in vivo , gene knockdown , liposome , breast cancer , stem cell , medicine , cancer , chemistry , materials science , biology , nanotechnology , microbiology and biotechnology , apoptosis , biochemistry
Targeted therapy for breast cancer stem cell (BCSC) : A novel liposomal system (APT EDB ‐LS‐siRNA EDB ) that enables simultaneous targeting and knockdown of extra domain B of fibronectin (EDB‐FN) shows potent therapeutic efficacy in the BCSC‐derived tumors in vivo.