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Graphene Oxides Show Angiogenic Properties
Author(s) -
Mukherjee Sudip,
Sriram Pavithra,
Barui Ayan Kumar,
Nethi Susheel Kumar,
Veeriah Vimal,
Chatterjee Suvro,
Suresh Kattimuttathu Ittara,
Patra Chitta Ranjan
Publication year - 2015
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201500155
Subject(s) - angiogenesis , graphene , in vivo , reactive nitrogen species , cancer research , in vitro , enos , reactive oxygen species , neovascularization , protein kinase b , microbiology and biotechnology , nitric oxide , chemistry , nanotechnology , biology , materials science , biochemistry , signal transduction , nitric oxide synthase , endocrinology
Angiogenesis, a process resulting in the formation of new capillaries from the pre‐existing vasculature plays vital role for the development of therapeutic approaches for cancer, atherosclerosis, wound healing, and cardiovascular diseases. In this report, the synthesis, characterization, and angiogenic properties of graphene oxide (GO) and reduced graphene oxide (rGO) have been demonstrated, observed through several in vitro and in vivo angiogenesis assays. The results here demonstrate that the intracellular formation of reactive oxygen species and reactive nitrogen species as well as activation of phospho‐eNOS and phospho‐Akt might be the plausible mechanisms for GO and rGO induced angiogenesis. The results altogether suggest the possibilities for the development of alternative angiogenic therapeutic approach for the treatment of cardiovascular related diseases where angiogenesis plays a significant role.