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Cell and Tissue Imaging with Molecularly Imprinted Polymers as Plastic Antibody Mimics
Author(s) -
Kunath Stephanie,
Panagiotopoulou Maria,
Maximilien Jacqueline,
Marchyk Nataliya,
Sänger Jörg,
Haupt Karsten
Publication year - 2015
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201500145
Subject(s) - hyaluronic acid , molecularly imprinted polymer , materials science , cell , polymer , fluorescence , biophysics , antibody , chemistry , biochemistry , anatomy , medicine , selectivity , catalysis , physics , quantum mechanics , biology , immunology , composite material
Molecularly imprinted polymers can be used as “plastic antibodies” for cell and tissue imaging, as demonstrated using hyaluronan on cell surfaces as a model target. Fluorescent nanoparticles binding a hyaluronan substructure, glucuronic acid, are used to image fixated and living cells and tissues. Plastic antibodies can be tailored to specific targets and easily labeled, and are physically and chemically stable.