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Dual Release Carriers for Cochlear Delivery
Author(s) -
Rahmani Sahar,
Ross Astin M.,
Park TaeHong,
Durmaz Hakan,
Dishman Acacia F.,
Prieskorn Diane M.,
Jones Nathan,
Altschuler Richard A.,
Lahann Joerg
Publication year - 2016
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201500141
Subject(s) - cochlea , materials science , controlled release , neurotrophic factors , guinea pig , dual (grammatical number) , biophysics , dual role , chemistry , biomedical engineering , neuroscience , nanotechnology , medicine , biology , biochemistry , receptor , art , literature , combinatorial chemistry
The fabrication of a carrier system capable of selectively encapsulating two therapeutics , piribedil and glial cell derived neurotrophic factor, in select compartments, and the programming of their independent release rates is investigated. The characterization of these particles, the release of each therapeutic, and the persistence of the particles within Guinea pig cochlea are assessed.