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Light Weight and Flexible High‐Performance Diagnostic Platform
Author(s) -
Karnaushenko Daniil,
Ibarlucea Bergoi,
Lee Sanghun,
Lin Gungun,
Baraban Larysa,
Pregl Sebastian,
Melzer Michael,
Makarov Denys,
Weber Walter M.,
Mikolajick Thomas,
Schmidt Oliver G.,
Cuniberti Gianaurelio
Publication year - 2015
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201500128
Subject(s) - materials science , wafer , transistor , fabrication , polyimide , bending , nanotechnology , optoelectronics , detection limit , nanowire , composite material , electrical engineering , voltage , medicine , alternative medicine , pathology , layer (electronics) , engineering , statistics , mathematics
A flexible diagnostic platform is realized and its performance is demonstrated for early detection of avian influenza virus (AIV) subtype H1N1 DNA sequences. The key component of the platform is high‐performance biosensors based on high output currents and low power dissipation Si nanowire field effect transistors (SiNW‐FETs) fabricated on flexible 100 μm thick polyimide foils. The devices on a polymeric support are about ten times lighter compared to their rigid counterparts on Si wafers and can be prepared on large areas. While the latter potentially allows reducing the fabrication costs per device, the former makes them cost efficient for high‐volume delivery to medical institutions in, e.g., developing countries. The flexible devices withstand bending down to a 7.5 mm radius and do not degrade in performance even after 1000 consecutive bending cycles. In addition to these remarkable mechanical properties, on the analytic side, the diagnostic platform allows fast detection of specific DNA sequences of AIV subtype H1N1 with a limit of detection of 40 × 10 −12 m within 30 min suggesting its suitability for early stage disease diagnosis.