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Intracellularly Degradable, Self‐Assembled Amphiphilic Block Copolycurcumin Nanoparticles for Efficient In Vivo Cancer Chemotherapy
Author(s) -
Lv Li,
Guo Yuan,
Shen Yuanyuan,
Liu Jieying,
Zhang Wenjun,
Zhou Dejian,
Guo Shengrong
Publication year - 2015
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201500075
Subject(s) - in vivo , ethylene glycol , doxorubicin , amphiphile , nanoparticle , drug , cancer cell , pharmacology , chemistry , cancer , materials science , nanotechnology , chemotherapy , medicine , biology , organic chemistry , microbiology and biotechnology , surgery , copolymer , polymer
Intracellularly degradable, self‐assembled amphiphilic biotin‐poly(ethylene glycol)‐ b ‐poly(curcumin‐dithiodipropionic acid) nanoparticles are developed. They display excellent in vivo anticancer efficacy, benefitted from their high tumor‐targeted accumulation and stimuli‐triggered intracellular drug release. They can be loaded with other anticancer drugs (e.g., doxorubicin) to exploit the synergy of combinational dual‐drug therapy to further enhance in vivo anticancer efficacy.