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Cell Microenvironment: Confinement and Deformation of Single Cells and Their Nuclei Inside Size‐Adapted Microtubes (Adv. Healthcare Mater. 11/2014)
Author(s) -
Koch Britta,
Sanchez Samuel,
Schmidt Christine K.,
Swiersy Anka,
Jackson Stephen P.,
Schmidt Oliver G.
Publication year - 2014
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201470059
Subject(s) - materials science , nanotechnology , deformation (meteorology) , cell , biophysics , composite material , chemistry , biology , biochemistry
Biofunctionalized glass microtube structures serve as transparent cell culture scaffolds and are fabricated to impose spatial confinement on single cells on page 1753. S. Sanchez, C. K. Schmidt, and colleagues demonstrate the influence of the resulting cell deformation on the integrity of the nucleus of human osteosarcoma cells and on cell division. Their findings underline the versatility of the rolled‐up microtubes for mimicking space restrictions present in physiological tissues.