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Organic Bioelectronics: Biomimetic Interfaces Reveal Activation Dynamics of C‐Reactive Protein in Local Microenvironments (Adv. Healthcare Mater. 11/2014)
Author(s) -
Goda Tatsuro,
Kjall Peter,
Ishihara Kazuhiko,
RichterDahlfors Agneta,
Miyahara Yuji
Publication year - 2014
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201470054
Subject(s) - bioelectronics , phosphorylcholine , materials science , nanotechnology , biophysics , membrane , polymer , chemistry , biosensor , biochemistry , biology , composite material
Alternation in local ionic microenvironments transforms the binding kinetics of pentameric C‐reactive protein to its receptor phosphorylcholine on a cell‐membrane‐mimetic surface. On page 1733 T. Goda and team show the biomimetic interface composed of a custom polymer and an organic bioelectronics to be a powerful tool in revealing the coherent picture of acute phase responses during inflammation and infection at molecular resolution.