Premium
Drug Delivery: Macromolecular Prodrugs of Ribavirin: Concerted Efforts of the Carrier and the Drug (Adv. Healthcare Mater. 9/2014)
Author(s) -
Smith Anton A. A.,
Wohl Benjamin M.,
Kryger Mille B. L.,
Hedemann Natasha,
GuerreroSanchez Carlos,
Postma Almar,
Zelikin Alexander N.
Publication year - 2014
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201470047
Subject(s) - prodrug , ribavirin , drug , macromolecule , drug delivery , pharmacology , chemistry , combinatorial chemistry , materials science , nanotechnology , medicine , biochemistry , genotype , gene
Automated parallel synthesis is applied by A. Postma, A. Zelikin, and team on page 1404 to obtain libraries of macromolecular prodrugs of ribavirin. Polymers differ in their average molar mass and drug content, the two parameters independently vary in broad respective ranges. Screening the libraries for intracellular activity identifies at least 10 formulations with efficacy matching that of the drug and at the same time significantly reducing toxicity.