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Stem Cells: Reconstituting Vascular Microenvironment of Neural Stem Cell Niche in Three‐Dimensional Extracellular Matrix (Adv. Healthcare Mater. 9/2014)
Author(s) -
Shin Yoojin,
Yang Kisuk,
Han Sewoon,
Park HyunJi,
Seok Heo Yun,
Cho SeungWoo,
Chung Seok
Publication year - 2014
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201470043
Subject(s) - extracellular matrix , neural stem cell , microbiology and biotechnology , niche , stem cell niche , matrix (chemical analysis) , stem cell , biology , chemistry , progenitor cell , biochemistry , chromatography
On page 1457 S.‐W. Cho, S. Chung, and co‐workers show that neural stem cell (NSC)‐vascular niche consisting of a brain vasculature and 3D extracellular matrix (ECM) is reconstituted in a microfluidic system. The in vivo‐like microenvironment reconstituted in this system allows NSCs to adopt physiologically relevant phenotypes through the combined effects of 3D ECM and vasculature.