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Drug Delivery: Enzyme‐Responsive Cell‐Penetrating Peptide Conjugated Mesoporous Silica Quantum Dot Nanocarriers for Controlled Release of Nucleus‐Targeted Drug Molecules and Real‐Time Intracellular Fluorescence Imaging of Tumor Cells (Adv. Healthcare Mater. 8/2014)
Author(s) -
Li Jinming,
Liu Fang,
Shao Qing,
Min Yuanzeng,
Costa Marianne,
Yeow Edwin K. L.,
Xing Bengang
Publication year - 2014
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201470038
Subject(s) - nanocarriers , mesoporous silica , nanomedicine , drug delivery , conjugated system , intracellular , nanotechnology , targeted drug delivery , cytotoxicity , biophysics , quantum dot , nanoparticle , chemistry , materials science , biochemistry , in vitro , mesoporous material , biology , polymer , catalysis , organic chemistry
On page 1230, B. Xing, E. K. L. Yeow, and co‐workers present a specific tumor microenvironment‐responsive silica quantum dot nano‐platform where potent antitumor reagents are loaded onto the surface of enzyme activatable cell penetrating peptide conjugated nanoparticles. This personalized nanomedicine platform can be specifically recognized by enzymes found only over‐expressed in the tumor cell environment that can selectively control the localized drug release into the nucleus of targeted tumor cells, eliciting significant tumor cytotoxicity with minimum side effects. This platform also provides real‐time imaging of the tumor targeting process and intracellular drug delivery.