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Antigens: Polymer Blend Particles with Defined Compositions for Targeting Antigen to Both Class I and II Antigen Presentation Pathways (Adv. Healthcare Mater. 5/2014)
Author(s) -
Tran Kenny K.,
Zhan Xi,
Shen Hong
Publication year - 2014
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201470026
Subject(s) - antigen , cross presentation , antigen presentation , antigen processing , immune system , mhc class i , cd8 , antigen presenting cell , microbiology and biotechnology , immunology , chemistry , biology , t cell
Blend nanoparticles, composed of a blend of polymers, serve as a vaccine delivery platform to deliver encapsulated antigens to dendritic cells. On page 690, blend particles control the delivery of antigens to both endolysosomal compartments and cytosolic space. Hong Shen and team show how, by controlling the polymer composition nanoparticles, protein antigens access to both MHC Class I and II antigen presentation pathways, engaging humoral, CD 4+ and CD 8+ T ‐ cell mediated immune responses.