Premium
Gene Delivery: Nonendocytic Delivery of Lipoplex Nanoparticles into Living Cells Using Nanochannel Electroporation (Adv. Healthcare Mater. 5/2014)
Author(s) -
Boukany Pouyan E.,
Wu Yun,
Zhao Xi,
Kwak Kwang J.,
Glazer Piotr J.,
Leong Kam,
Lee L. James
Publication year - 2014
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201470023
Subject(s) - electroporation , gene delivery , nanotechnology , healthcare delivery , nanoparticle , materials science , genetic enhancement , chemistry , health care , gene , biochemistry , economics , economic growth
Pouyan E. Boukany, L. James Lee, and colleagues have now found a safe, and efficient way to deliver nanoparticles containing a wide range of therapeutic agents into living cells without going through the endocytosis route, by applying electrical pulses through a nanochannel. The nanofluidic device introduced on page 682 represents a novel platform for in vitro nucleic acid delivery in regulating gene expression and holds great potential in advancing fundamental biological science and modifying cells for biomedical applications.