Premium
Vaccine Delivery: Nanocomposite‐Strengthened Dissolving Microneedles for Improved Transdermal Delivery to Human Skin (Adv. Healthcare Mater. 4/2014)
Author(s) -
Yan Li,
Raphael Anthony P.,
Zhu Xiaoyue,
Wang Beilei,
Chen Wei,
Tang Tao,
Deng Yan,
Sant Himanshu J.,
Zhu Guangyu,
Choy Kwong Wai,
Gale Bruce K.,
Prow Tarl W.,
Chen Xianfeng
Publication year - 2014
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201470018
Subject(s) - transdermal , materials science , pig skin , nanocomposite , biomedical engineering , nanotechnology , human skin , polymer , drug delivery , dermis , composite material , medicine , pharmacology , anatomy , biology , genetics
Xianfeng Chen and colleagues report a nanomaterial strengthened dissolvable polymer microneedle patch for efficient transdermal delivery. On page 555, this novel type of nanocomposite microneedle arrays can penetrate human and pig skin more reliably than pure polymer ones, release payload within only 1 min of insertion to skin, and induce significantly stronger immune response in mouse model in comparison with conventional subcutaneous injection.