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S‐Nitrosated Polypropylene Sulfide Nanoparticles for Thiol‐Dependent Transnitrosation and Toxicity Against Adult Female Filarial Worms
Author(s) -
Schudel Alex,
Kassis Timothy,
Dixon J. Brandon,
Thomas Susan N.
Publication year - 2015
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201400841
Subject(s) - nitric oxide , toxicity , brugia malayi , chemistry , thiol , nanoparticle , biochemistry , nanotechnology , filariasis , medicine , immunology , materials science , organic chemistry , helminths
A synthetic polymer nanoparticle formulation utilizing the physiological nitrosothiol chemistry for nitric oxide delivery is shown. Toxicity of S‐nitroso nanoparticles against adult female Brugia malayi worms, which are responsible for lymphatic filariasis, is dependent on nitric oxide release through transnitrosation as S‐nitrosocysteine, a potent endogenous nitric oxide donor.