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Collagen Scaffolds Incorporating Coincident Gradations of Instructive Structural and Biochemical Cues for Osteotendinous Junction Engineering
Author(s) -
Caliari Steven R.,
Weisgerber Daniel W.,
Grier William K.,
Mahmassani Ziad,
Boppart Marni D.,
Harley Brendan A. C.
Publication year - 2015
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201400809
Subject(s) - biomaterial , computer science , scaffold , tissue engineering , service (business) , compartment (ship) , interface (matter) , tendon , human–computer interaction , biomedical engineering , biology , anatomy , engineering , database , geology , oceanography , economy , bubble , maximum bubble pressure method , parallel computing , economics
A fully 3D biomaterial containing overlapping gradations of structural, compositional, and biomolecular cues as seen in native orthopedic interfaces is described for the first time. A multi‐compartment collagen scaffold is created for engineering tendon‐bone junctions connected by a continuous interface that can induce spatially specific MSC differentiation down tenogenic and osteogenic lineages without the use of differentiation media.