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Cartilage Tissue Engineering: Recent Advances and Perspectives from Gene Regulation/Therapy
Author(s) -
Li KueiChang,
Hu YuChen
Publication year - 2015
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201400773
Subject(s) - cartilage , tissue engineering , regeneration (biology) , articular cartilage , genetic enhancement , biology , microbiology and biotechnology , medicine , gene , anatomy , osteoarthritis , pathology , genetics , alternative medicine
Diseases in articular cartilages affect millions of people. Despite the relatively simple biochemical and cellular composition of articular cartilages, the self‐repair ability of cartilage is limited. Successful cartilage tissue engineering requires intricately coordinated interactions between matrerials, cells, biological factors, and phycial/mechanical factors, and still faces a multitude of challenges. This article presents an overview of the cartilage biology, current treatments, recent advances in the materials, biological factors, and cells used in cartilage tissue engineering/regeneration, with strong emphasis on the perspectives of gene regulation (e.g., microRNA) and gene therapy.