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Heparin‐Engineered Mesoporous Iron Metal‐Organic Framework Nanoparticles: Toward Stealth Drug Nanocarriers
Author(s) -
Bellido Elena,
Hidalgo Tania,
Lozano Maria Victoria,
Guillevic Mazheva,
SimónVázquez Rosana,
SantanderOrtega Manuel J.,
GonzálezFernández África,
Serre Christian,
Alonso Maria J.,
Horcajada Patricia
Publication year - 2015
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201400755
Subject(s) - nanocarriers , materials science , mesoporous material , nanoparticle , surface modification , coating , biopolymer , protein adsorption , nanotechnology , porosity , chemical engineering , nanobiotechnology , nanomedicine , polymer , chemistry , organic chemistry , composite material , catalysis , engineering
The specific modification of the outer surface of the promising porous metal‐organic framework nanocarriers (nanoMOFs) preserving their characteristic porosity is still a major challenge. Here a simple, fast, and biofriendly method for the external functionalization of the benchmarked mesoporous iron(III) trimesate nanoparticles MIL‐100(Fe) with heparin, a biopolymer associated with longer‐blood circulation times is reported. First, the coated nanoparticles showed intact crystalline structure and porosity with improved colloidal stability under simulated physiological conditions, preserving in addition its encapsulation and controlled release capacities. The effect of the heparin coating on the nanoMOF interactions with the biological environment is evaluated through cell uptake, cytotoxicity, oxidative stress, cytokine production, complement activation, and protein adsorption analysis. These results confirmed that the heparin coating endowed the nanoMOFs with improved biological properties, such as reduced cell recognition, lack of complement activation, and reactive oxygen species production. Overall, the ability to coat the surface of the nanoMOFs using a simple and straight‐forward approach could be taken as a way to enhance the versatility and, thus, the potential of porous MOF nanoparticles in biomedicine.