Premium
A Multifunctional Probe with Aggregation‐Induced Emission Characteristics for Selective Fluorescence Imaging and Photodynamic Killing of Bacteria Over Mammalian Cells
Author(s) -
Gao Meng,
Hu Qinglian,
Feng Guangxue,
Tomczak Nikodem,
Liu Rongrong,
Xing Bengang,
Tang Ben Zhong,
Liu Bin
Publication year - 2015
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201400654
Subject(s) - fluorescence , aggregation induced emission , bacteria , biophysics , gram negative bacteria , photodynamic therapy , chemistry , nanotechnology , biochemistry , materials science , escherichia coli , biology , organic chemistry , optics , genetics , physics , gene
A multifunctional probe aggregation‐induced emission‐Zinc(II)‐dipicolylamine (AIE‐ZnDPA) is developed for selective targeting, fluorescence imaging, and photodynamic killing of both Gram‐positive and Gram‐negative bacteria over mammalian cells. The probe has significant advantages in simple probe design, enhanced fluorescence upon bacteria binding, excellent photostability, and broad‐spectrum antibacterial activity with almost no harm to mammalian cells.