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Microfluidic Chip for Site‐Specific Neuropharmacological Treatment and Activity Probing of 3D Neuronal “Optonet” Cultures
Author(s) -
Marom Anat,
Mahto Sanjeev Kumar,
Shor Erez,
TenenbaumKatan Janna,
Sznitman Josué,
Shoham Shy
Publication year - 2015
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201400643
Subject(s) - microfluidics , microfluidic chip , nanotechnology , neuroscience , 3d printed , neural activity , materials science , biomedical engineering , biology , medicine
The study introduces a “brain‐on‐a‐chip” microfluidic platform that hosts brain‐like 3D cultures (“optonets”) whose activity and responses to flowing drugs are recorded optically. Optonets are viable, optically accessible 3D neural networks whose characteristics approximate cortical networks. The results demonstrate the ability to monitor complex 3D activity patterns during extended site‐specific, reversible neuropharmacogical exposure, suggesting an interesting potential in drug screening.