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From Flab to Fab: Transforming Surgical Waste into an Effective Bioactive Coating Material
Author(s) -
Luo Baiwen,
Yuan Shaojun,
Foo Selin Ee Min,
Wong Marcus Thien Chong,
Lim Thiam Chye,
Tan Nguan Soon,
Choong Cleo
Publication year - 2015
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201400514
Subject(s) - extracellular matrix , decellularization , coating , materials science , polycaprolactone , biological materials , regenerative medicine , biomedical engineering , tissue engineering , nanotechnology , chemistry , cell , polymer , composite material , biochemistry , medicine
Cellular events are regulated by the interaction between integrin receptors in the cell membrane and the extracellular matrix (ECM). Hence, ECM, as a material, can potentially play an instructive role in cell–material interactions. Currently, adipose tissue in the form of lipoaspirate is often discarded. Here, it is demonstrated how our chemical‐free decellularization method could be used to obtain ECM from human lipoaspirate waste material. These investigations show that the main biological components are retained in the lipoaspirate‐derived ECM (LpECM) material and that this LpECM material could subsequently be used as a coating material to confer bioactivity to an otherwise inert biodegradable material (i.e., polycaprolactone). Overall, lipoaspirate material, a complex blend of endogenous proteins, is effectively used a bioactive coating material. This work is an important stepping‐stone towards the development of biohybrid scaffolds that contain cellular benefits without requiring the use of additional biologics based on commonly discarded lipoaspirate material.