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CpG‐Loaded Multifunctional Cationic Nanohydrogel Particles as Self‐Adjuvanting Glycopeptide Antitumor Vaccines
Author(s) -
Hartmann Sebastian,
Nuhn Lutz,
Palitzsch Björn,
Glaffig Markus,
Stergiou Natascha,
Gerlitzki Bastian,
Schmitt Edgar,
Kunz Horst,
Zentel Rudolf
Publication year - 2015
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201400460
Subject(s) - glycopeptide , epitope , adjuvant , conjugate , cpg oligodeoxynucleotide , oligonucleotide , immune system , cpg site , chemistry , cationic polymerization , antibody , microbiology and biotechnology , immunology , medicine , biology , biochemistry , mathematical analysis , gene expression , dna methylation , mathematics , gene , antibiotics , dna , organic chemistry
Self‐adjuvanting antitumor vaccines by multifunctional cationic nanohydrogels loaded with CpG . A conjugate consisting of tumor‐associated MUC1‐glycopeptide B‐cell epitope and tetanus toxin T‐cell epitope P2 is linked to cationic nanogels. Oligonucleotide CpG complexation enhances toll‐like receptor (TLR) stimulated T‐cell proliferation and rapid immune activation. This co‐delivery promotes induction of specific MUC1‐antibodies binding to human breast tumor cells without external adjuvant.