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Hydrogel Design of Experiments Methodology to Optimize Hydrogel for iPSC‐NPC Culture
Author(s) -
Lam Jonathan,
Carmichael S. Thomas,
Lowry William E.,
Segura Tatiana
Publication year - 2015
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201400410
Subject(s) - self healing hydrogels , computer science , chemistry , organic chemistry
Bioactive signals can be incorporated in hydrogels to direct encapsulated cell behavior. Design of experiments methodology methodically varies the signals systematically to determine the individual and combinatorial effects of each factor on cell activity. Using this approach enables the optimization of three ligands concentrations (RGD, YIGSR, IKVAV) for the survival and differentiation of neural progenitor cells.