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Photopatterning of Multifunctional Hydrogels to Direct Adult Neural Precursor Cells
Author(s) -
Tsurkan Mikhail V.,
Wetzel Richard,
PérezHernández Heidi R.,
Chwalek Karolina,
Kozlova Anna,
Freudenberg Uwe,
Kempermann Gerd,
Zhang Yixin,
Lasagni Andrés F.,
Werner Carsten
Publication year - 2015
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201400395
Subject(s) - self healing hydrogels , ethylene glycol , matrix (chemical analysis) , in vitro , computer science , polymer , service (business) , materials science , nanotechnology , chemistry , polymer chemistry , biochemistry , business , organic chemistry , composite material , marketing
Matrix‐metalloproteinase and photosensitive peptide units are combined with heparin and poly(ethylene glycol) into a light‐sensitive multicomponent hydrogel material. Localized degradation of the hydrogel matrix allows the creation of defined spatial constraints and adhesive patterning for cells grown in culture. Using this matrix system, it is demonstrated that the degree of confinement determines the fate of neural precursor cells in vitro.