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Poly( N ‐vinylcaprolactam): A Thermoresponsive Macromolecule with Promising Future in Biomedical Field
Author(s) -
Liu Ji,
Debuigne Antoine,
Detrembleur Christophe,
Jérôme Christine
Publication year - 2014
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201400371
Subject(s) - self healing hydrogels , copolymer , nanotechnology , drug delivery , materials science , micelle , biocompatible material , polymer , monomer , thermoresponsive polymers in chromatography , chemistry , polymer chemistry , biomedical engineering , organic chemistry , aqueous solution , engineering , high performance liquid chromatography , reversed phase chromatography , composite material
Poly( N ‐vinylcaprolactam) (PNVCL) is a thermoresponsive and biocompatible polymer that raises an increasing interest in the biomedical area, especially in drug delivery systems (DDS) that include micelles, hydrogels, and hybrid particles. The thermoresponsiveness of PNVCL, used alone or in combination with other stimuli‐ responsive polymers or particles (pH, magnetic field, or chemicals), is often key in the loading and/or release process in these DDS. The renewed focus on this polymer, which is known for decades, is to a large extent due to recent progress in synthetic strategies. Especially, the advent of efficient controlled radical polymerization (CRP) methods for NVCL monomer gives now access to unprecedented well‐defined NVCL‐based copolymers with unique properties. This Review article addresses up‐to‐date synthetic aspects, biological features, and biomedical applications of the latest NVCL‐containing systems.